Articles
2022年
- Development of enzymatic depletion methods for preparation of small extracellular vesicles with long blood-circulation half-life.
Kobayashi Y, Kitamura S, Takahashi Y, Takakura Y.
Pharm Res, in press. 2022 Oct 4. doi: 10.1007/s11095-022-03405-9.
PMID: 36195822
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- Development of allergic rhinitis immunotherapy using antigen-loaded small extracellular vesicles.
Liu W, Ota M, Tabushi M, Takahashi Y, Takakura Y.
J Control Release. 2022 Mar 14;345:433-442.
PMID: 35301052
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- Development of hydrophobic interaction-based DNA supramolecules as efficient delivery carriers of CpG DNA to immune cells.
Koichi Ito, Mustumi Kariya, Kento Yasui, Yuki Takahashi, Yoshinobu Takakura.
J Pharm Sci. 2022;111(4):1133-1141. doi:10.1016/j.xphs.2021.11.027.
PMID: 34871560
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- Enhanced Immunostimulatory Activity of Covalent DNA Dendrons.
Kawamoto Y, Liu W, Yum J H, Park S, Sugiyama H, Takahashi Y, Takakura Y.
ChemBioChem. 2022,23. doi:10.1002/cbic.202100583.
PMID: 34881505
2021年
- Interleukin-4-carrying small extracellular vesicles with a high potential as anti-inflammatory therapeutics based on modulation of macrophage function.
Takenaka M, Yabuta A, Takahashi Y, Takakura Y.
Biomaterials. 2021 Nov;278:121160. doi: 10.1016/j.biomaterials.2021.121160. Epub 2021 Oct 9.
PMID: 34653934
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- Calcium Peroxide-Containing Polydimethylsiloxane-Based Microwells for Inhibiting Cell Death in Spheroids through Improved Oxygen Supply.
Mizukami Y, Takahashi Y, Shimizu K, Konishi S, Takakura Y, Nishikawa M.
Biol Pharm Bull. 2021;44(10):1458-1464. doi: 10.1248/bpb.b21-00269.
PMID: 34602554
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- Combined use of chemically modified nucleobases and nanostructured DNA for enhanced immunostimulatory activity of CpG oligodeoxynucleotide.
Araie Y, Ohtsuki S, Park S, Nagaoka M, Umemura K, Sugiyama H, Kusamori K, Takahashi Y, Takakura Y, Nishikawa M.
Bioorg Med Chem. 2021;29:115864. doi:10.1016/j.bmc.2020.115864.
PMID: 33223462
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- Critical contribution of macrophage scavenger receptor 1 to the uptake of nanostructured DNA by immune cells.
Umemura K, Ohtsuki S, Nagaoka M, Kusamori K, Inoue T, Takahashi Y, Takakura Y, Nishikawa M.
Nanomedicine. 2021;34:102386. doi:10.1016/j.nano.2021.102386.
PMID: 33774131
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- Determining The Role of Surface Glycans in The Pharmacokinetics of Small Extracellular Vesicles.
Yamamoto A, Yasue Y, Takahashi Y, Takakura Y.
J Pharm Sci. 2021;110(9):3261-3267. doi:10.1016/j.xphs.2021.05.021.
PMID: 34090899.
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- Phosphatidylserine-deficient small extracellular vesicle is a major somatic cell-derived sEV subpopulation in blood.
Matsumoto A, Takahashi Y, Ogata K, Kitamura S, Nakagawa N, Yamamoto A, Ishihama Y, Takakura Y.
iScience. 2021;24(8):102839. doi:10.1016/j.isci.2021.102839.
PMID:34368655.
2020年
- The identification of novel small extracellular vesicle (sEV) production modulators using luciferase-based sEV quantification method.
Yamamoto A, Takahashi Y, Inuki S, Nakagawa S, Nakao K, Ohno H, Doi M, Takakura Y.
J Extracell Biol, 2020; 1: e62
- Intracellular delivery o NF-κB inhibitor peptide utilizing small extracellular
vesicles for the application of anti-inflammatory therapy.
Takenaka M, Takahashi Y, Takakura Y.
J Control Release. 2020;328:435-443. doi:10.1016/j.jconrel.2020.09.001.
PMID: 32898592
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- Construction of Monomeric and Dimeric G-Quadruplex-Structured Cytosine-Phosphate-Guanine
Oligonucleotides for Enhanced Uptake and Activation in Toll-Like Receptor
9-Positive macrophages.
Liao W, Tan M, Kusamori K, Takakura Y, Nishikawa M.
Nucleic Acid Ther. 2020. doi:10.1089/nat.2019.0843. Online ahead of print.
PMID: 32559406
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- DNA density-dependent uptake of DNA origami-based two- or three-dimensional
nanostructures by immune cells.
Maezawa T, Ohtsuki S, Hidaka K, Sugiyama H, Endo M, Takahashi Y, Takakura
Y, Nishikawa M.
Nanoscale. 2020;12(27):14818-14824. doi:10.1039/d0nr02361b. PMID: 32633313.
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- Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide by the
Combination of Mannose Modification and Incorporation into Nanostructured
DNA.
Liao W, Akahira S, Hara RI, Wada T, Kusamori K, Takakura Y, Nishikawa M.
Biol Pharm Bull. 2020;43(8):1188-1195. doi:10.1248/bpb.b20-00052. PMID:
32741939.
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- Analysis of tertiary structural features of branched DNA nanostructures
with partially common sequences using small-angle X-ray scattering.
Tan M, Takahashi N, Fujii S, Sakurai K, Kusamori K, Takahashi Y, Takakura
Y, Nishikawa M.
ACS Applied Bio Materials. 2020, 3, 308-314.
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- Therapeutic Application of Small Extracellular Vesicles (sEVs): Pharmaceutical
and Pharmacokinetic Challenges.
Takakura Y, Matsumoto A, Takahashi Y.
Biol Pharm Bull. 2020;43:576-583. PMID: 32238700
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- Antitumor immunity by small extracellular vesicles collected from activated
dendritic cells through effective induction of cellular and humoral immune
responses.
Matsumoto A, Asuka M, Takahashi Y, Takakura Y.
Biomaterials. 2020;252:120112. PMID: 32422494
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- Development of CD40L-modified tumor small extracellular vesicles for the
effective induction of anti-tumor immune response.
Liu W, Takahashi Y, Morishita M, Nishikawa M, Takakura Y.
Nanomedicine (Lond). 2020 Jul;15(17):1641-1652. doi: 10.2217/nnm-2020-0071.
PMID: 32664826
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- Incorporation of gelatin microspheres into HepG2 human hepatocyte spheroids
for functional improvement through improved oxygen supply to spheroid core.
Mizukami Y, Moriya A, Takahashi Y, Shimizu K, Konishi S, Takakura Y, Nishikawa
M.
Biol Pharm Bull. 2020;43(8):1220-1225. doi: 10.1248/bpb.b20-00141. PMID:
32741942
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- Development of RNA/DNA Hydrogel Targeting Toll-Like Receptor 7/8 for Sustained
RNA Release and Potent Immune Activation.
Komura F, Okuzumi K, Takahashi Y, Takakura Y, Nishikawa M.
Molecules. 2020 Feb 7; 25(3):728. doi: 10.3390/molecules25030728. PMID:
32046113
2019年
- Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance
Cell Engraftment.
Takashima I, Kusamori K, Hakariya H, Takashima M, Vu TH, Mizukami Y, Noda
N, Takayama Y, Katsuda Y, Sato SI, Takakura Y,Nishikawa M, Uesugi M.
ACS Chem Biol. 2019 Apr 19; 14(4): 775-783.
- Effects of Localization of Antigen Proteins in Antigen-Loaded Exosomes
on Efficiency of Antigen Presentation.
Arima Y, Liu W, Takahashi Y,Nishikawa M, Takakura Y.
Mol Pharm. 2019 Jun 3; 16(6): 2309-2314.
- Regulation of the distribution of cells in mixed spheroids by altering migration direction.
Mizukami Y, Takahashi Y, Shimizu K, Konishi S, Takakura Y, Nishikawa M.
Tissue Eng Part A. 2019 Mar; 25(5-6): 390-398
- Development of a Nanostructured RNA/DNA Assembly as an Adjuvant Targeting
Toll-Like Receptor 7/8.
Komura F, Takahashi Y, Inoue I, Takakura Y, Nishikawa M.
Nucleic Acid Ther. 2019 Dec; 29(6): 335-342
- Development of DNA-anchored assembly of small extracellular vesicle for
efficient antigen delivery to antigen presenting cells.
Matsumoto A, Takahashi Y, Ariizumi R, Nishikawa M, Takakura Y.
Biomaterials. 2019 Dec; 225: 119518
- Folding of single-stranded circular DNA into rigid rectangular DNA accelerates
its cellular uptake.
Ohtsuki S, Shiba Y, Maezawa T, Hideka K, Sugiyama H, Endo M, Takahashi
Y, Takakura Y, Nishikawa M.
Nanoscale. 2019 Dec 28;11(48): 23416-23422
- Blood concentrations of small extracellular vesicles are determined by
a balance between abundant secretion and rapid clearance.
Matsumoto A, Takahashi Y, Chang HY, Wu YW, Yamamoto A, Ishihama Y, Takakura
Y.
J Extracell Vesicles. 2019 Nov 26; 9(1): 1696517
2018
- Preservation of exosomes at room temperature using lyophilization.
Charoenviriyakul C, Takahashi Y, Nishikawa M, Takakura Y.
Int J Pharm. 2018, 553(1-2), 1-7.
- Combined encapsulation of a tumor antigen and immune cells using a self-assembling
immunostimulatory DNA hydrogel to enhance antigen-specific tumor immunity.
Umeki Y, Saito M, Kusamori K, Tsujimura M, Nishimura M, Takahashi Y, Takakura Y, Nishikawa M.
J Control Release. 2018, 288, 189-198.
- Development of orally-deliverable DNA hydrogel by microemulsification and chitosan coating.
Nomura D, Saito M, Takahashi Y, Takahashi Y, Takakura Y, Nishikawa M.
Int J Pharm. 2018, 547, 556-562.
- Enhanced Activity of Immunosuppressive Oligodeoxynucleotides by Incorporating
Them into Hexapod-Like Nanostructured DNA.
Araie Y, Takahashi Y, Takahashi Y, Takakura Y, Nishikawa M.
Biol Pharm Bull. 2018, 41, 564-569.
- Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application.
Yamashita T, Takahashi Y, Takakura Y.
Biol Pharm Bull. 2018, 41, 835-842.
- Construction of nanostructured DNA harbouring phosphorodiamidate morpholino
oligonucleotide for controlled tissue distribution in mice.
Takahashi Y, Araie Y, Nomura D, Takahashi Y, Sano K, Saji H, Takakura Y,
Nishikawa M.
J Drug Target. 2018, 26, 373-381.
- Role of extracellular vesicle surface proteins in the pharmacokinetics
of extracellular vesicles.
Charoenviriyakul C, Takahashi Y, Morishita M, Nishikawa M, Takakura Y.
Mol Pharm. 2018, 15, 1073-1080.
2017
- Control of polarization and tumoricidal activity of macrophages by multicellular
spheroid formation.
Tanaka Y, Nishikawa M, Mizukami Y, Kusamori K, Ogino Y, Nishimura S, Shimizu
K, Konishi S, Takahashi Y, Takakura Y.
J Control Release. 2017, 270, 177-183.
- Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins.
Hamana A, Takahashi Y, Tanioka A, Nishikawa M, Takakura Y.
Int J Pharm. 2017, 536, 310-317.
- SELEX-Based Screening of Exosome-Tropic RNA.
Yamashita T, Shinotsuka H, Takahashi Y, Kato K, Nishikawa M, Takakura Y.
Biol Pharm Bull. 2017, 40, 2140-2145.
- Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene.
Ohtsuki S, Takahashi Y, Inoue T, Takakura Y, Nishikawa M.
Sci Rep. 2017, 7, 13661.
- Enhanced Class I Tumor Antigen Presentation via Cytosolic Delivery of Exosomal
Cargos by Tumor-Cell-Derived Exosomes Displaying a pH-Sensitive Fusogenic
Peptide.
Morishita M, Takahashi Y, Nishikawa M, Ariizumi R, Takakura Y.
Mol Pharm. 2017, 14, 4079-4086.
- Elucidation of the Mechanism of Increased Activity of Immunostimulatory
DNA by the Formation of Polypod-like Structure.
Mohri K, Nagata K, Ohtsuki S, Toyama S, Nonomura M, Takahashi Y, Takakura
Y, Nishikawa M, Sakuma S.
Pharm Res. 2017, 34, 2362-2370.
- DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory
DNA hydrogel for tumor photothermal immunotherapy.
Yata T, Takahashi Y, Tan M, Nakatsuji H, Ohtsuki S, Murakami T, Imahori
H, Umeki Y, Shiomi T, Takakura Y, Nishikawa M.
Biomaterials. 2017, 146, 136-145.
- Evaluation of antiviral effect of type I, II, and III interferons on direct-acting antiviral-resistant hepatitis C virus.
Hamana A, Takahashi Y, Uchida T, Nishikawa M, Imamura M, Chayama K, Takakura Y.
Antiviral Res. 2017, 146, 130-138.
- Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by the Formation of Polypod-like Structure.
Mohri K, Nagata K, Ohtsuki S, Toyama S, Nonomura M, Takahashi Y, Takakura
Y, Nishikawa M, Sakuma S.
Pharm Res. 2017.
- Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-Modified DNA for Increased Antigen-Specific Immune Response.
Umeki Y, Saito M, Takahashi Y, Takakura Y, Nishikawa M.
Adv Healthc Mater. 2017, 6(20).
- Accelerated growth of B16BL6 tumor in mice through efficient uptake of
their own exosomes by B16BL6 cells.
Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul
C, Saji H, Takakura Y.
Cancer Sci. 2017, 108, 1803-1810.
- Using size-controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice.
Nishikawa T, Tanaka Y, Kusamori K, Mizuno N, Mizukami Y, Ogino Y, Shimizu
K, Konishi S, Takahashi Y, Takakura Y, Nishikawa M.
Biotechnol J. 2017, 12(8).
- In Vitro and In Vivo Stimulation of Toll-Like Receptor 9 by CpG Oligodeoxynucleotides
Incorporated Into Polypod-Like DNA Nanostructures.
Takahashi Y, Maezawa T, Araie Y, Takahashi Y, Takakura Y, Nishikawa M.
J Pharm Sci. 2017, 106, 2457-2462.
- Pharmacokinetics of Exosomes-An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics.
Morishita M, Takahashi Y, Nishikawa M, Takakura Y.
J Pharm Sci. 2017, 106, 2265-2269.
- Amelioration of Experimental Autoimmune Encephalomyelitis in Mice by Interferon-Beta
Gene Therapy, Using a Long-Term Expression Plasmid Vector.
Hamana A, Takahashi Y, Tanioka A, Nishikawa M, Takakura Y.
Mol Pharm. 2017, 14, 1212-1217.
- Optimization of Albumin Secretion and Metabolic Activity of Cytochrome
P450 1A1 of Human Hepatoblastoma HepG2 Cells in Multicellular Spheroids
by Controlling Spheroid Size.
Nishikawa T, Tanaka Y, Nishikawa M, Ogino Y, Kusamori K, Mizuno N, Mizukami
Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y.
Biol Pharm Bull. 2017, 40, 334-338.
- Targeted Delivery of Interferon Gamma Using a Recombinant Fusion Protein
of a Fibrin Clot-Binding Peptide With Interferon Gamma for Cancer Gene
Therapy.
- Ando M, Fujimoto M, Takahashi Y, Nishikawa M, Hamana A, Takakura Y.
- J Pharm Sci. 2017, 106, 892-897.
- Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan.
- Ishii-Mizuno Y, Umeki Y, Onuki Y, Watanabe H, Takahashi Y, Takakura Y,
Nishikawa M.
- Int J Pharm. 2017, 516, 392-400.
- Cell type-specific and common characteristics of exosomes derived from
mouse cell lines: Yield, physicochemical properties, and pharmacokinetics.
- Charoenviriyakul C, Takahashi Y, Morishita M, Matsumoto A, Nishikawa M,
Takakura Y.
- Eur J Pharm Sci. 2017, 96, 316-322.
- Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition
and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages.
Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul
C, Saji H, Takakura Y.
J Pharm Sci. 2017, 106, 168-175.
2016
- Exosome-based tumor antigens-adjuvant co-delivery utilizing genetically
engineered tumor cell-derived exosomes with immunostimulatory CpG DNA.
Morishita M, Takahashi Y, Matsumoto A, Nishikawa M, Takakura Y.
Biomaterials. 2016, 111, 55-65.
- Interferon-Inducible Mx Promoter-Driven, Long-Term Transgene Expression
System of Interferon-β for Cancer Gene Therapy.
Hamana A, Takahashi Y, Nishikawa M, Takakura Y.
Hum Gene Ther. 2016, 27, 936-945..
- Depressive symptoms as a side effect of Interferon-? therapy induced by
induction of indoleamine 2,3-dioxygenase 1.
Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak
K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y,
Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K.
Sci Rep. 2016,6:29920.
- Polypod-shaped DNAs: Small Angle X-ray Scattering and Immunostimulatory
Activity.
Sanada Y, Shiomi T, Okobira T, Tan M, Nishikawa M, Akiba I, Takakura Y,
Sakurai K.
Langmuir, 2016, 32, 3760-3765.
- Effect of transgene expression level per cell in mice livers on induction
of transgene-specific immune responses after hydrodynamic gene transfer.
Yin Y, Takahashi Y, Hamana A, Nishikawa M, Takakura Y.
Gene Therapy, 2016, 23, 565-571.
- Analysis and Control of in Vivo Kinetics of Exosomes for the Development of Exosome-based
DDS.
Takahashi Y, Nishikawa M, Takakura Y.
Yakugaku Zasshi, 2016, 136, 49-53.
- Application of Magnesium Pyrophosphate-Based Sponge-Like Microparticles
to Enhance the Delivery Efficiency and Adjuvant Effects of Polyriboinosinic-Polyribocytidylic
Acid in Immune Cells.
Takagi S, Takahashi Y, Sugimura K, Nishikawa M, Takakura Y.
J Pharm Sci. 2016, 105, 766-772.
- Effect of exosome isolation methods on physicochemical properties of exosomes
and clearance of exosomes from the blood circulation.
Yamashita T, Takahashi Y, Nishikawa M, Takakura Y.
Eur J Pharm Biopharm. 2016, 98,1-8.
- Increased Insulin Secretion from Insulin-Secreting Cells by Construction
of Mixed Multicellular Spheroids.
Kusamori K, Nishikiawa M, Mizuno N, Nishikawa T, Masuzawa A, Tanaka Y,
Mizukami Y, Shimizu K, Konishi S, Takahashi Y, Takakura Y.
Pharm Res.2016, 33, 247-256.
- Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic
acids to immune cells.
Nishida Y, Ohtsuki S, Araie Y, Umeki Y, Endo M, Emura T, Hidaka K, Sugiyama
H, Takahashi Y, Takakura Y, Nishikawa M.
Nanomedicine: Nanotechnology, Biology, and Medicine. 2016, 12, 123-130.
2015
- Efficient amplification of self-gelling polypod-like structured DNA by
rolling circle amplification and enzymatic digestion.
Tomoya Yata, Yuki Takahashi, Mengmeng Tan, Kumi Hidaka, Masayuki Endo,
Hiroshi Sugiyama, Yoshinobu Takakura, Makiya Nishikawa.
Sci Rep., 2015, 5, 14979
- Atomic force microscopy analysis of orientation and bending of oligodeoxynucleotides
in polypod-like structured DNA.
Shiomi T, Tan M, Takahashi N, Endo M, Emura T, Hidaka K, Sugiyama H, Takahashi
Y, Takakura Y, Nishikawa M..
Nano Research. 2015 Dec; 8(12): 3764-3771.
- Contribution of Epigenetic Modifications to the Decline in Transgene Expression
from Plasmid DNA in Mouse Liver.
Zang L, Nishikawa M, Ando M, Takahashi Y, Takakura Y.
Pharmaceutics. 2015 Aug; 7(3): 199-212.
- Induction of Potent Antitumor Immunity by Sustained Release of Cationic
Antigen from a DNA-Based Hydrogel with Adjuvant Activity.
Umeki Y, Mohri K, Kawasaki Y, Watanabe H, Takahashi R, Takahashi Y, Takakura
Y, Nishikawa M.
Advanced Functional Materials. 2015, 25, 5758-67
- Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory
Nucleic Acids to Immune Cells.
Ohtsuki S, Matsuzaki N, Mohri K, Endo M, Emura T, Hidaka K, Sugiyama H,
Takahashi Y, Ishiyama K, Kadowaki N, Takakura Y, Nishikawa M.
Nucleic Acid Therapeutics. 2015, 25, 245-53
- Molecular Design of Bisphosphonate-Modified
Proteins for Efficient Bone Targeting In Vivo.
Katsumi H, Sano J, Nishikawa M, Hanazawa K, Sakane T, Yamamoto A.
PLoS One.. 2015, 10.
- Self-assembling DNA dendrimer for effective delivery of immunostimulatory CpG DNA to immune cells.
Mohri K, Kusuki E, Ohtsuki S, Takahashi N, Endo M, Hidaka K, Sugiyama H,
Takahashi Y, Takakura Y, Nishikawa M.
Biomacromolecules. 2015, 16, 1095-1101.
- Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice.
Morishita M, Takahashi Y, Nishikawa M, Sano K, Kato K, Yamashita T, Imai
T, Saji H, Takakura Y.
J Pharm Sci. 2015 Feb;104(2):705-13.
- Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice.
Ishii-Mizuno Y, Umeki Y, Takahashi Y, Kato Y, Takabayashi T, Fujieda S, Takakura Y, Nishikawa M.
J Control Release. 2015 Feb 28;200:52-9.
- Macrophage-dependent clearance of systemically administered B16BL6-derived
exosomes from the blood circulation in mice.
Imai T, Takahashi Y, Nishikawa M, Kato K, Morishita M, Yamashita T, Matsumoto
A, Charoenviriyakul C, Takakura Y.
J Extracell Vesicles. 2015 Feb 9;4:26238.
2014
- Transplantation of insulin-secreting multicellular spheroids for the treatment
of type 1 diabetes in mice.
Kusamori K, Nishikawa M, Mizuno N, Nishikawa T, Masuzawa A, Shimizu K,
Konishi S, Takahashi Y, Takakura Y.
J Control Release. 2014 Jan 10;173:119-24
- Long-Term Elimination of
Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-γ Gene
Transfer.
Takahashi Y, Ando M, Nishikawa M, Hiraga N, Imamura M, Chayama K,
Takakura Y.
Hum Gene Ther Clin Dev. 2014 Mar;25(1):28-39
- Efficient delivery of
immunostimulatory DNA to mouse and human immune cells through the construction
of polypod-like structured DNA.
Uno S, Nishikawa M, Mohri K, Umeki Y, Matsuzaki N, Takahashi Y, Fujita
H, Kadowaki N, Takakura Y.
Nanomedicine. 2014 May;10(4):765-74.
- Injectable,
self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen
delivery.
Nishikawa M, Ogawa K, Umeki Y, Mohri K, Kawasaki Y, Watanabe H, Takahashi
N, Kusuki E, Takahashi R, Takahashi Y, Takakura Y.
J Control Release. 2014 Apr 28;180:25-32.
- DNA nanotechnology-based development of delivery systems for bioactive compounds.
Mohri K, Nishikawa M, Takahashi Y, Takakura Y.
Eur J Pharm Sci. 2014 Jul 16;58:26-33.
-
Enhancement of anticancer effect of interferon-γ gene transfer against
interferon-γ-resistant tumor by depletion of tumor-associated macrophages.
Kiyota T, Takahashi Y, Watcharanurak K, Nishikawa M, Ohara S, Ando M, Watanabe Y, Takakura Y
Mol Pharm. 2014 May 5;11(5):1542-9.
-
Removal of transgene-expressing cells by a specific immune response induced
by sustained transgene expression.
Yin Y, Takahashi Y, Ebisuura N, Nishikawa M, Takakura Y.
J Gene Med. 2014 Mar-Apr;16(3-4):97-106.
-
Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity.
Watcharanurak K, Zang L, Nishikawa M, Yoshinaga K, Yamamoto Y, Takahashi Y, Ando M, Saito K, Watanabe Y, Takakura Y.
Gene Ther. 2014 Jun 12.
- X-ray scattering from immunostimulatory tetrapod-shaped DNA in aqueous solution to explore its biological activity-conformation relationship.
Sanada Y, Sakamoto S, Shiomi T, Okobira T, Mylonas E, Ohta N, Yagi N, Nishikawa
M, Akiba I, Takakura Y, Sakurai K.
J Phys Chem B. 2014 Sep 4;118(35):10373-9.
- Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell Transplantation.
Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya
J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N,
Uesugi M.
Angew Chem Int Ed Enql. 2014 Oct 13;53(42):11208-13.
- Prevention of adverse events of interferon γ gene therapy by gene
delivery of interferon γ-heparin-binding domain fusion protein
in mice.
Ando M, Takahashi Y, Yamashita T, Fujimoto M, Nishikawa M, Watanabe Y,
Takakura Y.
Molecular Therapy ? Methods & Clinical Development . 2014 1, 14023
2013
- Regulation of immunological
balance by sustained interferon-γ gene transfer for acute phase of atopic
dermatitis in mice.
Watcharanurak K, Nishikawa M, Takahashi Y, Kabashima K,
Takahashi R, Takakura Y.
Gene Ther. 2013 May;20(5):538-44
- Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6
cells in mice after intravenous injection.
Takahashi Y, Nishikawa M, Shinotsuka H, Matsui Y, Ohara S, Imai T,
Takakura Y.
J Biotechnol. 2013 May 20;165(2):77-84
- Poly(N-isopropylacrylamide)-coated
microwell arrays for construction and recovery of multicellular spheroids.
Shimizu K, Kusamori K, Nishikawa M, Mizuno N, Nishikawa T, Masuzawa A,
Katano S, Takahashi Y, Takakura Y, Konishi S.
J Biosci Bioeng. 2013 Jun;115(6):695-9
- Small-molecule-induced
clustering of heparan sulfate promotes cell adhesion.
Takemoto N, Suehara T, Frisco H, Sato S, Sezaki T, Kusamori K, Kawazoe
Y, Park SM, Yamazoe S, Mizuhata Y, Inoue R, Miller Gavin, Hansen S, Jayson
G, Gardiner J, Kanaya T, Tokitoh N, Ueda K, Takakura Y, Kioka N, Nishikawa
M, Uesugi M.
J Am Chem Soc. 2013 Jul 31;135(30):11032-9
- Gene delivery of albumin
binding peptide-interferon-gamma fusion protein with improved pharmacokinetic
properties and sustained biological activity.
Miyakawa N, Nishikawa M, Takahashi Y, Ando M,
Misaka M, Watanabe Y, Takakura Y.
J Pharm Sci. 2013 Sep;102(9):3110-8
- Expression profile-dependent improvement of insulin sensitivity by gene
delivery of interleukin-6 in a mouse model of type II diabetes.
Mukumoto H, Takahashi Y, Ando M, Nishikawa M, Takakura Y.
Mol Pharm. 2013 Oct 7;10(10):3812-21
2012
- Development of safe and
effective nonviral gene therapy by eliminating CpG motifs from plasmid DNA
vector.
Takahashi Y, Nishikawa M, Takakura Y.
Front Biosci (Schol Ed). 2012 Jan 1;4:133-41.
- Comparison of antigen
expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing
mice.
Guan X, Nishikawa M, Li H, Takahashi Y, Takakura Y.
Hum Vaccin Immunother. 2012 Feb;8(2):194-200.
- Constant and steady transgene expression of interferon-γ by optimization
of plasmid construct for safe and effective interferon-γ gene therapy.
Ando M, Takahashi Y, Nishikawa M, Watanabe Y, Takakura Y.
J Gene Med. 2012 Apr;14(4):288-95
- Near-infrared
fluorescence probes for enzymes based on binding affinity modulation of
squarylium dye scaffold.
Oushiki D, Kojima H, Takahashi Y, Komatsu T, Terai T, Hanaoka K, Nishikawa
M, Takakura Y, Nagano T.
Anal Chem. 2012 May 15;84(10):4404-10
- Design and development
of nanosized DNA assemblies in polypod-like structures as efficient vehicles
for immunostimulatory CpG motifs to immune cells.
Mohri K, Nishikawa M, Takahashi N, Shiomi T, Matsuoka N, Ogawa K, Endo
M, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y.
ACS Nano. 2012 Jul 24;6(7):5931-40
- Self-assembling CpG DNA
nanoparticles for efficient antigen delivery and immunostimulation.
Rattanakiat S, Nishikawa M, Takakura Y.
Eur J Pharm Sci. 2012 Sep 29;47(2):352-8
- Fibronectin inhibits
cytokine production induced by CpG DNA in macrophages without direct binding to
DNA.
Yoshida H, Nishikawa M, Yasuda S, Toyota H, Kiyota T, Takahashi Y, Takakura
Y.
Cytokine. 2012 Oct;60(1):162-70
- Increased immunostimulatory activity of polypod-like structured DNA by
ligation of the terminal loop structures.
Mohri K, Takahashi N, Nishikawa M, Kusuki E, Shiomi T, Takahashi Y, Takakura
Y.
J Control Release. 2012 Nov 10;163(3):285-92
- Controlling the kinetics of interferon transgene expression for improved
gene therapy.
Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y.
J Drug Target. 2012 Nov;20(9):764-9
- Control of spatiotemporal distribution of interferon γ by genetically fusing
functional peptides.
Ando M, Takahashi Y, Nishikawa M, Takakura Y.
Yakugaku Zasshi. 2012;132(12):1399-406
2011
- Inhibition of surgical
trauma-enhanced peritoneal dissemination of tumor cells by human catalase
derivatives in mice.
Nishizaki C, Nishikawa M, Yata T, Yamada T, Takahashi Y, Oku M, Yurimoto
H, Sakai Y, Nakanishi K, Takakura Y. Free Radic Biol Med., 51(3):773-9
(2011)
- Increase in CpG
DNA-induced inflammatory responses by DNA oxidation in macrophages and mice.
Yoshida H, Nishikawa M,
Kiyota T, Toyota H, Takakura Y. Free Radic Biol Med., 51(2):424-31 (2011)
- Saturation of transgene
protein synthesis from mRNA in cells producing a large number of transgene
mRNA.
Takahashi Y, Nishikawa
M, Takiguchi N, Suehara T, Takakura Y. Biotechnol Bioeng., in press
- Nucleic acid drug
delivery and targeting.
Takakura Y. Pharm Res., 28(4):691-3
(2011)
- 5'-Phosphate
oligodeoxynucleotides enhance the phosphodiester-CpG DNA-induced inflammatory
response in macrophages.
Yoshida H, Nishikawa M,
Kiyota T, Uno S, Toyota H, Takahashi R, Narita M, Takakura Y. Eur J Immunol., 41(2):425-36
(2011)
- Prolonged circulation
half-life of interferon γ activity by gene delivery of interferon γ-serum
albumin fusion protein in mice.
Miyakawa N, Nishikawa M,
Takahashi Y, Ando M, Misaka M, Watanabe Y, Takakura Y. J Pharm Sci.,
100(6):2350-7 (2011)
- Inhibition of nuclear
delivery of plasmid DNA and transcription by interferon γ: hurdles to be
overcome for sustained gene therapy.
Zang L, Nishikawa M,
Machida K, Ando M, Takahashi Y, Watanabe Y, Takakura Y. Gene Ther., 18(9):891-7
(2011)
2010
- Persistent interferon transgene expression by RNA interference-mediated
silencing of interferon receptors.
Takahashi
Y, Vikman E, Nishikawa M, Ando M, Watanabe Y, Takakura Y.
J Gene Med. 2010 Sep; 12(9): 739-746
- Sustained exogenous expression of therapeutic levels of IFN-gamma ameliorates
atopic dermatitis in NC/Nga mice via Th1 polarization.
Hattori
K, Nishikawa M, Watcharanurak K, Ikoma A, Kabashima K, Toyota H, Takahashi Y,
Takahashi R, Watanabe Y, Takakura Y.
J Immunol. 2010 Mar;184(5), 2729-2735
- Injection site-dependent
induction of immune response by DNA vaccine: comparison of skin and spleen as a
target for vaccination.
Guan X, Nishikawa M, Takemoto S, Ohno Y, Yata
T, Takakura Y.
J Gene Med. 2010 Mar;12(3), 301-309
- Comparison of the type of liposome involving cytokine production induced
by non-CpG Lipoplex in macrophages.
Yasuda S, Yoshida H, Nishikawa M, Takakura Y.
Mol Pharm. 2010 Apr 5;7(2), 533-542
- Development of a novel Hsp70-based DNA vaccine as a multifunctional antigen delivery system.
Yamaoka
A, Guan X, Takemoto S, Nishikawa M, Takakura Y.
J Control Release. 2010 Mar 19;142(3), 411-415
- Bootstrap method-based estimation of the minimum sample number for obtaining
pharmacokinetic parameters in preclinical experiments.Takemoto
S, Yamaoka K, Nishikawa M, Yano Y, Takakura Y.
J Pharm Sci. 2010 Apr;99(4), 2176-2184
2009
- Control of hypoxia-induced tumor cell adhesion by cytophilic human catalase.
Yata T, Nishikawa M, Nishizaki C, Oku M, Yurimoto H, Sakai Y, Takakura Y.
Free Radic Biol Med. 2009 Dec 15;47(12):1772-8. Epub 2009 Oct 3. Abstract (PubMed)
- Induction of tumor-specific immune response by gene transfer of Hsp70-cell penetrating peptide fusion protein to tumors in mice
Makiya Nishikawa, Takayuki Otsuki, Atsushi Ota, Xin Guan, Seiji Takemoto,
Yuki Takahashi and Yoshinobu Takakura
Mol Ther. 2009 Sep 1. [Epub ahead of print] Abstract (PubMed)
- The assembly of a short linear natural cytosine-phosphate-guanine DNA into
dendritic structures and its effect on immunostimulatory activity
Sakulrat Rattanakiat, Makiya Nishikawa, Hisakage Funabashi, Dan Luo and Yoshinobu Takakura
Biomaterials. 2009 Oct;30(29):5701-6. Abstract (PubMed)
- Effects of methyl-β-cyclodextrin treatment on secretion profile of interferon-β
and ZO-1 architecture in MDCK cell monolayers
Masato Maruyama, Kayo Ishida, Yoshihiko Watanabe, Makiya Nishikawa and Yoshinobu Takakura
Biol Pharm Bull. 2009 May;32(5):910-5.Abstract (PubMed)
- TLR9-depdendent systemic interferon-beta production by intravenous injection of plasmid DNA/cationic liposome complex in mice
Hiroyuki Yoshida, Makiya Nishikawa, Sachiyo Yasuda, Yumiko Mizuno, Hiroyasu Toyota, Tsuyoshi Kiyota, Rei Takahashi and Yoshinobu Takakura
J Gene Med. 2009 Aug;11(8):708-17. Abstract (PubMed)
- Nonviral vector-mediated RNA interference: its gene silencing characteristics
and important factors to achieve RNAi-based gene therapy
Yuki Takahashi, Makiya Nishikawa and Yoshinobu Takakura
Adv Drug Deliv Rev. 2009 Jul 25;61(9):760-6. Abstract (PubMed)
- Enhanced CTL response by controlled intracellular trafficking of antigen
in dendritic cells following DNA vaccination
Keiko Isaji, Atsushi Kawase, Mitsuhiro Matono, Xin Guan, Makiya Nishikawa and Yoshinobu Takakura
J Control Release. 2009 May 5;135(3):227-33. Abstract (PubMed)
- Effect of the content of unmethylated CpG dinucleotides in plasmid DNA
on sustainability of transgene expression
Masaru Mitsui, Makiya Nishikawa, Lei Zang, Mitsuru Ando, Kayoko Hattori, Yuki Takahashi, Yoshihiko Watanabe and Yoshinobu Takakura
J Gene Med. 2009 May;11(5):435-43. Abstract (PubMed)
- Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis
Makiya Nishikawa, Mitsuru Hashida, Yoshinobu Takakura
Adv Drug Deliv Rev. 2009 Apr 28;61(4):319-26. Abstract (PubMed)
2008
- Reactivation of Silenced Transgene Expression in Mouse Liver by Rapid, Large-volume Injection of Isotonic Solution.
Makiya Nishikawa, Ayumi Nakayama, Yuki Takahashi, Yasushi Fukuhara and
Yoshinobu Takakura
Hum Gene Ther. 2008 Oct;19(10):1009-20. Abstract (PubMed)
- Gene silencing of beta-catenin in melanoma cells retards their growth but
promotes the formation of pulmonary metastasis in mice.
Yuki Takahashi, Makiya Nishikawa, Tetsuya Suehara, Naomi Takiguchi and
Yoshinobu Takakura
Int J Cancer. 2008 Nov 15;123(10):2315-20. Abstract (PubMed)
- Unique cytokine production profile following stimulation with DNA in macrophages
from NZB/W F1 mice
Yoshiyuki Ogawa, Takaharu Yoshinaga, Makiya Nishikawa and Yoshinobu Takakura
Biol Pharm Bull. 2008 Jun;31(6):1244-9. Abstract (PubMed)
- Quantitative and temporal analysis of gene silencing in tumor cells induced
by small interfering RNA or short hairpin RNA expressed from plasmid vectors
Yuki Takahashi, Kiyoshi Yamaoka, Makiya Nishikawa and Yoshinobu Takakura
J Pharm Sci. 2009 Jan;98(1):74-80. Abstract (PubMed)
- Inhibition of tumor cell growth in the liver by RNA interference-mediated
suppression of HIF-1α expression in tumor cells and hepatocytes
Yuki Takahashi, Makiya Nishikawa and Yoshinobu Takakura
Gene Ther. 2008 Apr;15(8):572-82. Abstract (PubMed)
- Cellular activation by plasmid DNA in various macrophages in primary culture
Hiroyuki Yoshida, Makiya Nishikawa, Sachiyo Yasuda, Yumiko Mizuno and Yoshinobu
Takakura
J Pharm Sci. 2008 Oct;97(10):4575-85. Abstract (PubMed)
- Enhanced immunostimulatory activity of oligonucleotides by Y-shape formation
Makiya Nishikawa, Mitsuhiro Matono, Sakulrat Rattanakiat, Nao Matsuoka
and Yoshinobu Takakura
Immunology. 2008 Jun;124(2):247-55.Abstract (PubMed)
2007
- Effects of inflammatory response on in vivo transgene expression by plasmid
DNA in mice
Keiko Kako, Makiya Nishikawa, Hiroyuki Yoshida and Yoshinobu Takakura
J Pharm Sci. 2007 Dec 6;97(8):3074-3083. Abstract (PubMed)
- Hsp-based tumor vaccines: state-of-the-art and future directions
Yoshinobu Takakura, Seiji Takemoto and Makiya Nishikawa.
Curr Opin Mol Ther. 2007 Aug;9(4):385-91. Abstract (PubMed)
- Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA
Hiroki Kawano, Makiya Nishikawa, Masaru Mitsui, Yuki Takahashi, Keiko Kako,
Kiyoshi Yamaoka, Yoshihiko Watanabe and Yoshinobu Takakura
International journal of Cancer. 2007 Jul 15;121 (2):401-6. Abstract (PubMed)
- Plasmid DNA uptake and subsequent cellular activation characteristics in
human monocyte-derived cells in primary culture
Yuga Fukuhara, Tomoyuki Naoi, Yoshiyuki Ogawa, Makiya Nishikawa and Yoshinobu
Takakura
Journal of Pharmaceutical Sciences. 2007 Jun;96 (6):1576-84. Abstract (PubMed)
- Design of PCR-amplified DNA fragments for in vivo gene delivery: size-dependency
on stability and transgene expression
Kazuhiro Hirata, Makiya Nishikawa, Naoki Kobayashi, Yuki Takahashi and
Yoshinobu Takakura
Journal of Pharmaceutical Sciences. 2007 Mar 23; in press. Abstract (PubMed)
- DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells
Takaharu Yoshinaga, Kei Yasuda, Yoshiyuki Ogawa, Makiya Nishikawa and Yoshinobu
Takakura
Immunology. 2007 Mar;120 (3):295-302. Abstract (PubMed)
- Induction of antigen-specific cytotoxic T lymphocytes by immunization with
negatively charged soluble antigen through scavenger receptor-mediated
delivery
Yasuomi Yamasaki, Tomoko Ikenaga, Takayuki Otsuki, Makiya Nishikawa and Yoshinobu
Takakura
Vaccine. 2007 Jan 2;25(1):85-91. Abstract (PubMed)
2006
- Histgram analysis of pharmacokinetic parameters by bootstrap resampling
from one-point data in animal experiments
Seiji Takemoto, Kiyoshi Yamaoka, Makiya Nishikawa and Yoshinobu Takakura
Drug Metabolism and Pharmacokinetics. 2006 Dec;21 (6):458-64. Abstract (PubMed)
- Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting beta-catenin or hypoxia-inducible factor 1alpha
Yuki Takahashi, Makiya Nishikawa and Yoshinobu Takakura
J
Control Release. 2006 Nov 10;116 (1):90-5. Abstract (PubMed)
- Enhanced antigen-specific antibody production following polyplex-based
DNA vaccination via the intradermal route in mice
Atsushi Kawase, Keiko Isaji, Ayumi Yamaoka, Naoki Kobayashi, Makiya Nishikawa
and Yoshinobu Takakura
Vaccine. 2006 Jul 7;24 (27-28):5535-45. Abstract (PubMed)
- Moment analysis for kinetics of gene silencing by RNA interference
Yuki Takahashi, Kiyoshi Yamaoka, Makiya Nishikawa and Yoshinobu Takakura
Biotechnol
Bioeng. 2006 Mar 5;93 (4):816-9. Abstract (PubMed)
2005
- Cellular uptake and activation characteristics of naked plasmid DNA and
its cationic liposome complex in human macrophages
Ikuko Yamane, Makiya Nishikawa and Yoshinobu Takakura
Int J
Pharm. 2005 Nov 23;305 (1-2):145-53. Abstract (PubMed)
- Sequence-specific suppression of mdr1a/1b expression in mice via RNA interference
Yumi Matsui, Naoki Kobayashi, Makiya Nishikawa and Yoshinobu Takakura
Pharm Res. 2005 Dec;22 (12):2091-8. Abstract (PubMed)
- The uptake and degradation of DNA is impaired in macrophages and dendritic
cells from NZB/W F(1) mice
Yoshiyuki Ogawa, Takaharu Yoshinaga, Kei Yasuda, Makiya Nishikawa and Yoshinobu Takakura
Immunol Lett. 2005 Oct 15;101 (1):32-40. Abstract (PubMed)
- Gene Silencing in primary and metastatic tumors bby small interfering RNA
delivery in mice: quantitative analysis using melanoma cells expressing
firefly and sea pansy luciferases
Yuki Takahashi, Makiya Nishikawa, Naoki
Kobayashi and Yoshinobu Takakura
J Control Release. 2005 Jul 20;105 (3):332-43. Abstract (PubMed)
- Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells
Masato Maruyama, Michiyuki Kishimoto, Kayo Ishida, Yoshihiko Watanabe, Makiya Nishikawa, S. Masuda, R. Sasaki and Yoshinobu Takakura
Arch Biochem Biophys. 2005 Jun 15;438 (2):174-81. Abstract (PubMed)
- Pharmacokinetic and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice
Seiji Takemoto, Makiya Nishikawa and Yoshinobu Takakura
Pharm Res. 2005 Mar ;22 (3):419-26.
Abstract (PubMed)
- Manipulation of local disposition and gene expression characteristics of plasmid DNA following intramuscular administration by complexation with cationic macromolecule
Atsushi Kawase, Naoki Kobayashi, Keiko Isaji, Makiya Nishikawa and Yoshinobu Takakura
Int J Pharm. 2005 Apr 11;293 (1-2):291-301.
Abstract (PubMed)
- Permeability modulation of human intestinal Caco-2 cell monolayers by interferons
Hiroko Kawaguchi, Yukiko Akazawa, Yoshihiko Watanabe and Yoshinobu Takakura
Eur J Pharm Biopharm. 2005 Jan;59 (1):45-50.
Abstract (PubMed)
- Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways
Kei Yasuda, Yoshiyuki Ogawa, Ikuko Yamane, Makiya Nishikawa and Yoshinobu Takakura
J Leukoc Biol. 2005 Jan;77 (1):71. Abstract (PubMed)
2004
- Analysis methods and recent advances in nonlinear pharmacokinetics from in vitro through in loci to in vivo
Kiyoshi Yamaoka and Yoshinobu Takakura
Drug Metab Pharmacokinet. 2004 Dec;19 (6):397-406
Abstract (PubMed)
- Secretion Mode and Subcellular Localization of Human Interferon- b Exogenously
Expressed in Porcine Renal Epithelial LLC-PK 1
Cells
Teruko Nishio, Masato Maruyama, Toyokazu Yoshida, Yoshihiko Watanabe, Makiya Nishikawa and Yoshinobu Takakura
Biol Pharm Bull. 2004 Oct;27 (10):1653.
Abstract (PubMed)
- Simultaneous Detection of DsRed2-tagged and EGFP-tagged Human b -Interferons
in the Same Single Cells
Masato Maruyama, Teruko Nishio, Toyokazu Yoshida, Chisaki Ishida, Kayo Ishida, Yoshihiko Watanabe, Makiya Nishikawa and Yoshinobu Takakura
J Cell Biochem. 2004 Sep 15;93 (3):497. Abstract (PubMed)
- Significant Role of Liver Sinusoidal Endothelial Cells in Hepatic Uptake and Degradation of Naked Plasmid DNA following Intravenous Injection
Jin Hisazumi, Naoki Kobayashi, Makiya Nishikawa and Yoshinobu Takakura
Pharm Res. 2004 Jul;21 (7):1223-1228.
Abstract (PubMed)
- Subcellular Trafficking of Exogenously Expressed Interferon- b in Madin-Darby
Canine Kidney Cells
Masato Maruyama, Teruko Nishio, Takako Kato, Toyokaza Yoshida, Chisaki Ishida, Yoshihiko Watanabe, Makiya Nishikawa, Yasufumi Kaneda and Yoshinobu Takakura
J Cell Physiol. 2004 Oct;201 (1):117-25.
Abstract (PubMed)
- Induction of Cytotoxic T Lymphocytes following Immunization with Cationized Soluble Antigen
Tomoko Ikenaga, Yasuomi Yamasaki, Kohsuke Shakushiro, Makiya Nishikawa and Yoshinobu Takakura
Vaccine. 2004 Jun 30;22 (20):2609-16.
Abstract (PubMed)
- Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells
Kohsuke Shakushiro, Yasuomi Yamasaki, Makiya Nishikawa and Yoshinobu Takakura
Immunology. 2004 Jun;112 (2):211-8.
Abstract (PubMed)
- Hydrodynamic-based Procedure Invovlves Transient Hyperpermeability in the Hepatic Cellular Membrane: Implication of a Nonspecific Process in Efficient Intracellular Gene Delivery
Naoki Kobayashi, Makiya Nishikawa, Kazauhiro Hirata and Yoshinobu Takakura
J Gene Med. 2004 May;6 (5):584-92.
Abstract (PubMed)
- Hepatic Delivery of Particulates in the Submicron Range by a Hydrodynamic-based Procedure: Implications for Particulate Gene Delivery Systems
Naoki Kobayashi, Kazuhiro Hirata, Shi Chen, Atsushi Kawase, Makiya Nishikawa and Yoshinobu Takakura
J Gene Med. 2004 Apr;6 (4):455-63.
Abstract (PubMed)
- Restricted Cytokine Production from Mouse Peritoneal Macrophages in Culture in spite of Extensive Uptake of Plasmid DNA
Kei Yasuda, Hiroki Kawano, Ikuko Yamane, Yoshiyuki Ogawa, Takaharu Yoshinaga, Makiya Nishikawa and Yoshinobu Takakura
Immunology. 2004 Mar;111 (3):282-90.
Abstract (PubMed)
- An Evaluation Method for Nonlinear Local Disposition in Rat Liver and Kidney
Takako Kato, Kiyoshi Yamaoka and Yoshinobu Takakura
Drug Metab Dispos. 2004 Feb;32(2):230-4.
Abstract (PubMed)
- Vector-based In Vivo RNA Interference : Dose- and Time- Dependent Suppression
of Transgene Expression
Naoki Kobayashi, Yumi Matsui, Atsushi Kawase, Kazuhiro Hirata, Makoto Miyagishi, Makiya Nishikawa and Yoshinobu Takakura
J Pharmacol Exp Ther.2004, Feb;308 (2):688-93. Abstract (PubMed)
- Effect of interferon g on the Pharmacokinetics of Digoxin, a P-glycoprotein
Substrate, Intravenously Injected into the Mice
Hiroko Kawaguchi, Yumi Matsui, Yoshihiko Watanabe and Yoshinobu Takakura
J Pharmacol Exp Ther. 2004 Jan;308 (1):91-6. Abstract (PubMed)
2003
- Disposition and Gene Expression Characteristics in Solid Tumors and Skeletal Muscle after Directe Injection of Naked Plasmid DNA in Mice
Atsushi Kawase, Takehiko Nomura, Kei Yasuda, Naoki Kobayashi, Mitsuru Hashida and Yoshinobu Takakura
J. Pharm. Shi. 2003 Jun;92 (6):1295-304.
Abstract (PubMed)
- Efficient scavenger receptor-mediated hepatic targeting of proteins by
introduction of negative charges on the proteins by aconitylation : the
influence of charge density and size of the proteins molecules
Yasuomi Yamasaki, Jin Hisazumi, Kiyoshi Yamaoka and Yoshinobu Takakura
Eur. J. Pharm. Shi. 2003 Apr;18 (5):305-12.
Abstract (PubMed)
2002
- Therapeutic Effect of intravenous interferon gene delivery with naked plasmid DNA in murine metastasis models
Naoki Kobayashi, Takeshi Kuramoto, Shi Chen, Yoshihiko Watanabe and Yoshinobu Takakura
Mol Ther. 2002 Dec;6 (6):737-44. Abstract (PubMed)
- Efficient uptke and rapid degradation of plasmid DNA by murine dendritic cells via a specific mechanism
Takaharu Yoshinaga, Kei Yasuda, Yoshiyuki Ogawa, and Yoshinobu Takakura
Biochem. Biophys. Res. Commun. 2002 Dec;299 (3):389-94.
Abstract (PubMed)
- Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes
Yukiko Akazawa, Hiroko Kawaguchi, Maki Funahashi, Yoshihiko Watanabe, Kiyoshi Yamaoka, Mitsuru Hashida and Yoshinobu Takakura
J. Pharm. Sci.2002 Oct;91 (10):2110-5.
Abstract (PubMed)
- Plasmid DNA Activates Murine Macrophages to Induce Inflammatory Cytokines in a CpG Motif-Independent Manner by Complex Formation with Cationic Liposomes
Kei Yasuda, Yoshiyuki Ogawa, Michiyuki Kishimoto, Toshihide Takagi, Mitsuru Hashida, and Yoshinobu Takakura
Biochem. Biophys. Res. Commun. 2002 Apr;293 (1):344-8.
Abstract (PubMed)
- Pharmacokinetic Analysis of In Vivo Disposition of Succinylated Proteins Targeted to Liver Non-parenchymal Cells via Scavenger Receptors: Importance of Molecular Size and Negative Charge Density for In Vivo Recognition by Receptors
Yasuomi Yamasaki, Kazuya Sumimoto, Makiya Nishikawa, Fumiyoshi Yamashita, Kiyoshi Yamaoka, Mitsuru Hashida and Yoshinobu Takakura
J. Pharmacol. Exp. Ther. 2002 May;301 (2):467-77.
Absract (PubMed)
2001
- Hepatic Uptake and Gene Expression Mechanisms following Intravenous Administration of Plasmid DNA by Conventional and Hydrodynamics-Based Procedures
Naoki Kobayashi, Takeshi Kuramoto Kiyoshi Yamaoka, Mitsuru Hashida, and Yoshinobu Takakura
J. Pharmacol. Exp. Ther. 2001 Jun;297 (3):853-60.
Abstract (PubMed)
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